O que a juventude negra do slam tem a dizer para a psicologia social? / What do slam black youth have to say to social psychology? / ¿qué tienen que decir la juventud negra del slam a la psicología social?

Resumo Este trabalho discute como as poesias no slam tensionam a sociedade no contexto do racismo em suas diversas dimensões. As rodas de slam são um espaço onde slammers expõem manifestos poéticos sobre racismo e formas de opressão e onde a juventude negra se inscreve no mundo por meio de sua narrativa, interagindo com seus iguais e produzindo relações que fortalecem, legitimam e valorizam suas vivências. A partir da abordagem afrocêntrica e afrorreferenciada, tomamos poesias de slammers como materialidade para problematizar o lugar que a temática racial ocupa na Psicologia Social, pensando o social como um campo problemático construído e produzido a partir de diferentes práticas humanas. Com isso, podemos abrir na roda da psicologia social uma fenda que desloca a produção de conhecimento a partir da pluriversalidade, ou seja, as possibilidades de as rodas de slam convidarem a psicologia social a compor teorias localizadas fora do círculo acadêmico ocidentocêntrico.

Resumen Este trabajo analiza cómo la poesía en slam tensiona a la sociedad en el contexto del racismo en sus diversas dimensiones. Las ruedas de slam son espacios donde los slammers exponen manifiestos poéticos sobre el racismo y las formas de opresión y donde los jóvenes negros se inscriben en el mundo a través de su narrativa, interactuando con sus pares y produciendo relaciones que fortalecen, legitiman y valoran sus vivencias. Desde un enfoque afrocéntrico y afroreferenciado, tomamos la poesía de slammers como materialidad para problematizar el lugar que ocupan los temas raciales en la Psicología Social, pensando en lo social como un campo problemático construido y producido a partir de diferentes prácticas humanas. Con esto, podemos abrir una brecha en la rueda de la psicología social que desplaza la producción de conocimiento de la pluriversalidad, es decir, las posibilidades de ruedas de slam para invitar a la psicología social a componer teorías ubicadas fuera del círculo académico occidental-céntrico.

Abstract This paper discusses how poetry in slam tensions society in the context of racism in its various dimensions. The slam wheels are spaces where slammers expose poetic manifestos about racism and other forms of oppression, and where black youth are inscribed in the world through their narratives, interacting with their peers and producing relations that strengthen, legitimize and value their experiences. From an Afrocentric and African-referenced approach, we take slammers poetry as materiality to problematize the place that racial themes occupy in Social Psychology, thinking of the social as a problematic field constructed and produced from different human practices. With this, we can open a crack in the circle of social psychology that displaces the production of knowledge from pluriversality, that is, the possibilities of slam wheels to invite social psychology to compose theories outside the Western-centered academic circle.

Escrever como um ato de resistência: uma escrita rizoma / Writing as an act of resistance: a rhizome writing / Escribir como un acto de resistencia: una escritura rizoma / Écrire comme un acte de résistance: une écriture rhizome

O movimento desta escrita acompanha o movimento de produção de tese intitulada: Novos coletivos de resistência em produção: o que pode um corpo político poético? É uma escrita rizoma. Portanto, uma escrita resistência e não sobre resistência. Anuncia os recolhimentos de campo, as transmutações e os encontros com os coletivos de resistência que se conectam às produções de mulheres poetas, pretas e moradoras da periferia da cidade de Belém-PA. Assim, é uma batalha, uma partilha e uma saúde. O artigo parte do encontro entre a pesquisadora, e poeta, da Faculdade de Saúde Pública da Universidade de São Paulo (USP), sua orientadora e militante do SUS, e as mulheres, manas, e poetas, de Belém e Manaus - AM, que fazem parte do coletivo Slam Dandaras do Norte, e que protagonizam encontros-batalhas de poesia, para produzir encontros poéticos, manifestos e atos que potencializem suas existências, demandas políticas, alegrias e produção de si.

The movement of this writing accompanies the thesis production movement entitled: New resistance groups being produced: what can a poetic political body? It is a rhizome writing. So a writing resistance, and not about resistance. It announces the field recollections, the transmutations and the encounters, with the resistance collectives that connect to the poetic productions of women poets, blacks and dwellers of the periphery of the city of Belém-PA. So it's a battle, a sharing and a health. The article starts with the cartographic experimentation between the researcher and poet, the University of São Paulo's School of Public Health (USP), its director and militant of the SUS, and the women, dudes, and poets of Belém and Manaus-AM, who are part of the collective Slam Dandaras do Norte, who play poetry encounters, to produce poetic encounters, manifestos and acts that potentiate their existences, political demands, joys and self-production.

El movimiento de esa escritura acompana el movimiento de producción de tesis titulada: Nuevos colectivos de resistencia en producción: iqué puede un cuerpo político poético? Es una escritura rizoma. Por lo tanto, una escritura resistencia y no sobre resistencia. Anuncia lo que há sido recogido en el campo, las transmutaciones y los encuentros con los colectivos de resistencia que se conectan a las producciones poéticas de mujeres poetas, negras y moradoras de la periferia de la ciudad de Belém-PA. Así, es una batalla, un compartir y una salud. El artículo parte de la experimentación cartográfica entre la investigadora y poeta, de la Facultad de Salud Pública de la Universidad de São Paulo (USP), su orientadora y militante del SUS, y las mujeres, manas, y poetas, de Belém y Manaus-AM, que forman parte del colectivo Slam Dandaras del Norte, y que protagonizan encuentros-batallas de poesía, para producir encuentros poéticos, manifiestos y actos que potencien sus existencias, demandas políticas, alegrias y producción de sí.

Le mouvement de cette écriture accompagne le mouvement de production de thèse intitulé: Nouveaux collectif de résistance en production: que peut un corps politique poétique? C'est un rhizome écrit. Donc, une résistance à l 'écriture et non une résistance excessive. Annonce le rassemblements sur le terrain, transmutations et rencontres avec des groupes de résistance qui se connectent aux productions de poètes, femmes noires et femmes vivant à la périphérie de ville de Belém-PA. C'est donc une bataille, un partage et une santé. L'article commence à partir du rencontre entre le chercheur et poète de la Faculté de Santé Publique de L'université de São Paulo (USP), son directeur et militant du SUS, et femmes, manas et poètes, de Belém et de Manaus-AM, qui font partie du collectif Slam Dandaras do Norte, et qui rencontres poétiques - batailles de poésie, pour produire des rencontres poétiques, des manifestes et des actes qui potentialisent leur existence, leurs revendications politiques, leurs joies et leur production.

Roles of signaling lymphocytic activation molecule expression on CD4 +T cells surface in the pathogenesis of allergic conjunctivitis / 眼科新进展

Objective To discuss the function of signaling lymphocytic activation molecule (SLAM) expression on CD4 + T cells surface in the pathogenesis of allergic conjunctivitis.Methods Totally 10 patients with allergic conjunctivitis were selected as the observation group,and 10 individuals with no history of allergies receiving physical examination were selected as the control group,followed by the collection of venous blood.The expression of total IgE in the serum was tested by ELISA,and the expression of SLAM on CD4 + T cell surface was assessed by using flow cytometry.Then the correlation between SLAM expression on CD4 +T cell surface and serum total IgE level were analyzed.Next,20 Balb/c mice (2-month old) were equally divided into two groups (control group and model group) at random,with 10 mice in each group.Model group was firstly sensitized with the mixture of ragweed and complete Freund's adjuvant by footpad and root of tail injection on day 1.On day 7 and 14,intraperitoneal injection was enhanced,while rats in the control group were intraperitoneally injected with equal amounts of Freund's adjuvant.On day 15,mice were excited by ragweed pollen crude infusion drops,and,after 1 h,the eyes were taken for histopathology testing.Then,peripheral blood was collected,and the whole blood was used for the detection of SLAM expression,while the serum was used for the detection of specific IgE for ragweed pollen.Finally,the difference between the two groups and the correlation between SLAM expression and specific IgE level were analyzed.Results The expression of SLAM on CD4 +T cell surface in the observation group was significantly decreased when compared with the healthy controls (P =0.016),but the total IgE level was significantly increased in allergic conjunctivitis patients (P =0.002);and there was a negative correlation between SLAM expression and total IgE level (r =-0.453 4,P ＜ 0.05).About mice,the expression of SLAM on CD4 + T cell surface of the model group was significantly lower than that of the control group (P =0.000).The expression level of specific IgE of the model group was significantly higher than that of the control group (P =0.000).And there was a negative correlation between SLAM expression and specific IgE level in the model group (r =-0.527 4,P ＜ 0.05).Conclusion In allergic conjunctivitis,the expression of SLAM on CD4 + T cell surface in peripheral blood is significantly decreased,which is correlated with the production of IgE,and this may reflect the disease severity to some extent.

Effect of the signaling lymphocytic activation molecule (SLAM) in the modulation of T cells in immune response to Leishmania braziliensis in vitro / Efeito da molécula de sinalização para ativação linfocítica (SLAM) na modulação de células T na resposta imune à Leishmania braziliensis in vitro

Introduction: Signaling lymphocyte activation molecule (SLAM) is a self-ligand receptor on the surface of activated T- and B-lymphocytes, macrophages, and DC. Studies have shown PBMC from healthy individuals exposed to Leishmania differ in IFN-γ production. Objective: We investigated the role of SLAM signaling pathway in PMBC from high (HP) and low (LP) IFN-γ producers exposed to L. braziliensis in vitro. Methods: PBMC from 43 healthy individuals were cultured with or without antigen, α-SLAM, rIL-12 and rIFN-γ. The cytokines production was evaluated by ELISA, and SLAM expression by flow cytometry. Results: L. braziliensis associated with rIFN-γ or rIL-12 reduced early SLAM but did not modify this response later in HP. α-SLAM did not alter CD3+SLAM+ expression, and not affected IFN-γ and IL-13 production, in both groups, but increased significantly IL-10 in HP. Leishmania associated with α-SLAM and rIL-12 increased IFN-γ in LP, as well as IL-13 in HP. LP group presented low IFN-γ and IL-13 production, and low SLAM expression. Conclusion: Collectively, these findings suggest that when PBMC from healthy individuals are sensitized with L. braziliensis in vitro, SLAM acts in modulating Th1 response in HP individuals and induces a condition of immunosuppression in LP individuals. (AU)

Introdução: A molécula de sinalização para ativação linfocítica (SLAM) é um receptor autoligante na superfície de linfócitos T e B ativados, macrófagos e DC. Estudos têm mostrado que PBMC de indivíduos saudáveis expostos à Leishmania diferem na produção de IFN-γ. Objetivo: Nós investigamos o papel da via de sinalização de SLAM em PMBC de altos produtores de IFN-γ (AP) e baixos (BP) expostos à L. braziliensis in vitro. Métodos: PBMC de 43 indivíduos saudáveis foram cultivadas com ou sem antígeno, α-SLAM, rIL-12 e rIFN-γ. Foi avaliada a produção de citocinas por ELISA e expressão de SLAM por citometria de fluxo. Resultados: L. braziliensis associado a rIFN-γ ou rIL-12 reduziu a expressão inicial de SLAM, mas não modificou esta resposta mais tarde em AP. α-SLAM não alterou a expressão de CD3+SLAM+, e não afetou a produção de IFN-γ e IL-13, em ambos os grupos, mas aumentou significativamente IL-10 em AP. Leishmania associada a α-SLAM e rIL-12 aumentou IFN-γ em BP, assim como IL-13 em AP. BP apresentaram baixa produção de IFN-γ e IL-13 e baixa expressão de SLAM. Conclusão: Coletivamente, esses achados sugerem que quando PBMC de indivíduos saudáveis são sensibilizados por L. braziliensis in vitro, SLAM atua na modulação da resposta Th1 em indivíduos AP e induz uma condição de imunossupressão em indivíduos BP. (AU)

SLAM and path planning of mobile robot in ROS framework / 医疗卫生装备

Objective To realize SLAM and path planning of mobile robot to solve the problem of real-time data association in the process of moving and to update the computational complexity of the state covariance matrix.Methods The mathematical model of SLAM was built,and FastSlam algorithm based on particle filter,A* and dynamic window approach (DWA) were used to prepare gmapping function package in the ROS framework.Results The motion simulation,path planning and dynamic obstacle avoidance of mobile robot in the ROS framework were realized.Conclusion By using ROS platform,mobile robots can execute path planning efficiently while completing self-localization and map building.

The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses

The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.

Clinical Significance of Anti-HSP 70 Antibody in the Patients with Systemic Lupus Erythematosus / 대한임상병리학회지

BACKGROUND: Heat shock proteins (HSPs), or stress proteins, are immunodominant antigens of many microorganisms. In this study, we have detected the anti-HSP 70 antibody and tried to explain the role of the antibody with respect to the pathogenesis of SLE. Furthermore, we have attempted to find out the possibility to link the presence of the autoantibody with the monitoring and diagnosis of systemic lupus erythematosus (SLE). METHODS: A total of 80 samples from 55 SLE patients were screened for the presence of anti-HSP 70 antibodies. Simultaneously 59 healthy people were tested as a control group. The anti-HSP 70 antibodies were measured by enzyme-linked immunosorbent assay (ELISA) and confirmed by western blot in anti-HSP 70 antibody ELISA positive samples. The activity of disease state was confirmed by the patients' medical record and systemic lupus activity measure (SLAM). RESULTS: The mean optical density (O.D.450) of ELISA in healthy controls and SLE patients were 0.15+/-0.18 (mean+/-S.D.) and 0.13+/-0.14. The correlation of SLAM Score and ELISA O.D. was r2=0.19, P=0.014. And, the mean O.D. value of ELISA was 0.18+/-0.02 and 0.11+/-0.01 before and after treatment (P <0.05). We compared samples with SLAM Score. The O.D. of anti-HSP 70 ELISA in these patients were 0.20+/-0.02 and 0.08+/-0.002 before and after treatment respectively (n=10, mean+/-S.D., P <0.01). CONCLUSIONS: Anti-HSP 70 antibody was not a clinically useful diagnostic marker in SLE patients. However, the titer of anti-HSP 70 antibody can be used for the monitoring of the therapeutic effectiveness in these patients.

Expression of SLAM gene in CD4~+ and CD8~+ T cells from SLE patients / 第三军医大学学报

Objective To explore the expression of SLAM gene in the CD4+ and CD8+ T cells from SLE patients.Method The CD4+ and CD8+ T cells from peripheral blood of 20 SLE patients and 10 healthy blood donors were separated using magnetic cell sorting system(MACS).We detected the expression of SLAM mRNA in CD4+ and CD8+ T cells by RT-PCR.Results The CD4+ and CD8+ T cells from SLE patients showed significantly higher SLAM expression than those from healthy blood donors.Conclusion The SLAM signal pathway may play an important role in contributing to the abnormal activation of T cells in SLE patients.